In this video we present a two-year-old female with a febrile urinary tract infection and E. coli bacteremia who presents with suspected parenteral diarrhea, a non-infectious diarrhea associated with an extra-intestinal infection. The concept of parenteral diarrhea is over a century old and generally accepted in the literature but there have been no high-quality studies to prove whether or not it is a real clinical entity. So what? Why does it matter. It matters because vomiting and diarrhea occurring as a non-infectious side effect of a urinary tract infection can cause diagnostic confusion and failure to diagnose a potentially serious illness. We include a discussion of our recently published retrospective chart review of children diagnosed with culture proven urinary tract infections. We looked for an association between urinary tract infections and reports of diarrhea. Is parenteral diarrhea just another medical myth or a real clinical entity?